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Model:

Name: Markevich_2005_MAPK_AllRandomElementary
Description:
Keywords:
References:
  • J Cell Biol 2004 Feb;164(3):353-9. Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. Markevich NI, Hoek JB, Kholodenko BN. Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust St., Philadelphia, PA 19107, USA.
  • Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M.(2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems. Nucleic Acids Res., 34: D689-D691.


    • Comment: Recommended TimeSpan 0 to 50
    Initial Conditions:
    Rates:



    Reactants: Reactions:
  • tyr phosphorylation of MAPK Math
  • thr phosphorylation of MAPK-PY Math
  • thr phosphorylation of MAPK Math
  • tyr phosphorylation of MAPK-PT Math
  • dephosphorylation of Tyr on MAPKP-PY Math
  • dephosphorylation of MAPK-PT Math
  • dephosphorylation of MAPK-PY Math
  • dephosphorylation of Thr on MAPK-PP Math
  • dissociation of MAPK-PT and MKP Math
  • dissociation of MAPK and MKP Math
  • dissociation MAPK and MKP Math
  • dissociation MAPK-PY and MKP Math
  • MAPK MAPKK binding Math
  • binding of MAPKK on MAPK-PY Math
  • binding of MAPKK on Thr site of MAPK Math
  • binding MAPK-PT and MAPKK Math
  • binding MKP on Tyr site of MAKP-PY Math
  • binding of MKP on Thr site of MAPK-PT Math
  • binding of MKP on Tyr site of MAPK-PY Math
  • binding of MKP on Thr site of MAPK-PP Math
  • tyr phosphorylation of MAPK
  • thr phosphorylation of MAPK-PY
  • thr phosphorylation of MAPK
  • tyr phosphorylation of MAPK-PT
  • dissociation of MAPK-PT and MKP
  • dissociation of MAPK and MKP
  • dissociation MAPK and MKP
  • dissociation MAPK-PY and MKP
  • MAPK MAPKK binding
  • binding of MAPKK on MAPK-PY
  • binding of MAPKK on Thr site of MAPK
  • binding MAPK-PT and MAPKK
  • binding MKP on Tyr site of MAKP-PY
  • binding of MKP on Thr site of MAPK-PT
  • binding of MKP on Tyr site of MAPK-PY
  • binding of MKP on Thr site of MAPK-PP
  • dephosphorylation of Tyr on MAPKP-PY
  • dephosphorylation of MAPK-PT
  • dephosphorylation of MAPK-PY
  • dephosphorylation of Thr on MAPK-PP