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Model:

Name: Markevich_2004_MAPK_phosphoRandomMM
Description:
Keywords:
References:
  • J Cell Biol 2004 Feb;164(3):353-9.Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. Markevich NI, Hoek JB, Kholodenko BN. Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust St., Philadelphia, PA 19107, USA.
  • Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M.(2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems. Nucleic Acids Res., 34: D689-D691.

  • Comment:
    Initial Conditions:
    Rates:



    Reactants:
  • M
  • MpY
  • MpT
  • Mpp
  • MEK
  • MKP3
  • Reactions:
  • M to MpY
  • MpY to Mpp
  • M to MpT
  • MpT to Mpp
  • Mpp to MpT
  • MpT to M
  • MpY to M
  • M to MpY
  • MpY to Mpp
  • M to MpT
  • MpT to Mpp
  • Mpp to MpT
  • MpT to M
  • MpY to M