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Model:

Name: Markevich_2004_MAPK_orderedMM2kinases
Description:
Keywords:
References:
  • J Cell Biol 2004 Feb;164(3):353-9. Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. Markevich NI, Hoek JB, Kholodenko BN. Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust St., Philadelphia, PA 19107, USA.
  • Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M.(2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems. Nucleic Acids Res., 34: D689-D691.


    • Comment:
    Initial Conditions:
    Rates:



    Reactants:
  • M
  • Mp
  • Mpp
  • MAPKK1
  • MAPKK2
  • MKP3
    • Reactions:
  • Mpp Dephosphorylation Math
  • Mp Dephosphorylation Math
  • M Phosphorylation Math
  • Mp Phosphorylation Math
  • M Phosphorylation
  • Mp Phosphorylation
  • Mpp Dephosphorylation
  • Mp Dephosphorylation