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Model:

Name: Markevich_2004_MAPK_orderedMM
Description:
Keywords:
References:
  • J Cell Biol 2004 Feb;164(3):353-9. Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. Markevich NI, Hoek JB, Kholodenko BN. Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust St., Philadelphia, PA 19107, USA.
  • Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M.(2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems. Nucleic Acids Res., 34: D689-D691.

    • Comment:
    Initial Conditions:
    Rates:



    Reactants:
  • M
  • Mp
  • Mpp
  • MAPKK
  • MKP3
    • Reactions:
  • M Phosphorylated by MAPKK Math
  • Mp Phosphorylated by MAPKK Math
  • Mpp Dephosphorylated by MKP3 math
  • Mp Dephosphorylated by MKP3 Math
  • M Phosphorylated by MAPKK Bio
  • Mp Phosphorylated by MAPKK Bio
  • Mpp Dephosphorylated by MKP3 Bio
  • Mp Dephosphorylated by MKP3 Bio