Model:
Name: Kholodenko_1999_EGFRsignaling
Description:
Keywords:
References:
J Biol Chem. 1999 Oct 15;274(42):30169-81. Quantification of short term signaling by the epidermal growth factor receptor. Markevich NI, Hoek JB, Kholodenko BN. Kholodenko BN, Demin OV, Moehren G, Hoek JB. Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Boris.Kholodenko@mail.tju.edu
Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M.(2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems. Nucleic Acids Res., 34: D689-D691.
Comment:
Reactants:
Reactions:
EGF binds to EGFR
Association of 2 Ra into dimer
Phosphorylation of R2
Binding of PLCg to RP
Phosphorylation of PLCg
Dissociation of RPLCgP
Binding of Grb2?to?RP
Binding of SOS to RG to RP
Dissociation of RGS
Dissociation of GS
Binding of Shc to RP
Phosphorylation of RSh
Dissociation of RShp
Binding of Grb2 to RShP
Dissociation of RShG
Binding of SOS to RShG
Dissociation of RShGS
Binding of Grb2 to ShP
Binding of SOS to ShG
Dissociation of ShGS
Association of RShP and GS
Translocation of PLCgP
Dephosphorylation of RP
Binding of PLCg to RP
Dephosphorylation of ShP
EGF binds to EGFR
Association of 2 Ra into dimer
Phosphorylation of R2
Dephosphorylation of RP
Binding of PLCg to RP
Dephosphorylation of ShP
Binding of PLCg to RP
Phosphorylation of PLCg
Dissociation of RPLCgP
Binding of Grb2?to?RP
Binding of SOS to RG to RP
Dissociation of RGS
Dissociation of GS
Binding of Shc to RP
Phosphorylation of RSh
Dissociation of RShp
Binding of Grb2 to RShP
Dissociation of RShG
Binding of SOS to RShG
Dissociation of RShGS
Binding of Grb2 to ShP
Binding of SOS to ShG
Dissociation of ShGS
Association of RShP and GS
Translocation of PLCgP
