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Model:

Name: Bullock_and_Fersht_2001_p53
Description:
Keywords:
References:
  • Bullock and Fersht (2001) Nature Reviews Cancer 1(1):68-76

    • Comment:
    Initial Conditions:
    Rates:



    Reactants:
  • p53
  • p53pSer15
  • p53pSer392
  • p21
  • MDM2
  • p53Ub
  • FourteenThreeThreeSigma
  • FAS
  • BAX
  • p53AIP
  • GADD45
  • p14ARF
  • DNAPK
  • CKII
  • p14ARFMDM2
  • P
    • Reactions:
  • Phosphorylation of p53 on Ser15 Math
  • Dephosphorylation of p53 on Ser15 Math
  • Phosphorylation of p53 on Ser392 Math
  • Dephosphorylation of p53 on Ser392 Math
  • Ubiquitinylation of p53 by MDM2 Math
  • Annihilation of p14ARF Math
  • Annihilation of DNAPK Math
  • Annihilation of CKII Math
  • Annihilation of MDM2 Math
  • Annihilation of p53Ub Math
  • Annihilation of p21 Math
  • Annihilation of BAX Math
  • FAS Annihilation math
  • Annihilation of p53AIP Math
  • GADD45 Annihilation Math
  • Annihilation of FourteenThreeThreeSigma Math
  • Creation of p14ARF Math
  • Creation of p53 Math
  • Sequesteration of MDM2 by p14ARF Math
  • Transcriptional induction of p21 by p53pSer15 Math
  • Transcriptional induction of MDM2 by p53 Math
  • Transcriptional induction of MDM2 by p53pSer15 Math
  • Transcriptional induction of MDM2 by p53pSer392 Math
  • Transcriptional induction of FourteenThreeThreeSigma by p53pSer392 Math
  • Transcriptional induction of FAS by p53pSer15 Math
  • Transcriptional induction of BAX by p53pSer15 Math
  • Transcriptional induction of p53AIP by p53pSer15 Math
  • Transcriptional induction of FAS by p53pSer392 Math
  • Transcriptional induction of BAX by p53pSer392 Math
  • Transcriptional induction of p53AIP by p53pSer392 Math
  • Transcriptional induction of GADD45 by p53pSer15 Math
  • Transcriptional induction of GADD45 by p53pSer392 Math
  • Transcriptional induction of p21 by p53pSer15
  • Transcriptional induction of MDM2 by p53
  • Transcriptional induction of MDM2 by p53pSer15
  • Transcriptional induction of MDM2 by p53pSer392
  • Transcriptional induction of FourteenThreeThreeSigma by p53pSer392
  • Transcriptional induction of FAS by p53pSer15
  • Transcriptional induction of BAX by p53pSer15
  • Transcriptional induction of p53AIP by p53pSer15
  • Transcriptional induction of FAS by p53pSer392
  • Transcriptional induction of BAX by p53pSer392
  • Transcriptional induction of p53AIP by p53pSer392
  • Transcriptional induction of GADD45 by p53pSer15
  • Transcriptional induction of GADD45 by p53pSer392
  • Annihilation of p14ARF
  • Annihilation of DNAPK
  • Annihilation of CKII
  • Annihilation of MDM2
  • Annihilation of p53Ub
  • Annihilation of p21
  • Annihilation of BAX
  • FAS Annihilation
  • Annihilation of p53AIP
  • GADD45 Annihilation
  • Annihilation of FourteenThreeThreeSigma
  • Creation of p14ARF
  • Creation of p53
  • Sequesteration of MDM2 by p14ARF
  • Phosphorylation (Dephosphorylation) of p53 on Ser15 by DNAPK (P)
  • Phosphorylation (Dephosphorylation) of p53 on Ser392 by CKII (P)
  • Ubiquitinylation of p53 by MDM2